By Steve Kirsch Mar 14, 2021 Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for a single drug to be 100% successful. The drugs mechanisms of action were explained to the KOL panel which voted 2>1 in favor of fluvoxamine. On January 22, 2021, thirty key opinion leaders (KOL) from NIH, CDC, and leading academic institutions met to review the evidence for using fluvoxamine for treating COVID. The medical community doesnt care about saving lives. I must admit that this is an anniversary that snuck Everyone is stunned, but nobody is surprised. And that is what has allowed Kirsch, and people like him, to become so influential. fluvoxamine The fast, easy, safe, simple, low cost treatment for COVID that has worked 100% of the time to prevent hospitalization that nobody wants to talk about We now have a viable solution to reduce COVID hospitalization and mortality; Read More fluvoxamine Got COVID? In every case we are aware of, the drug was successful in reversing COVID symptoms, generally in 3 days or less. Kirsch, though, often relies on the heartstrings to smooth over a lack of data. Steve Kirsch: Vaccine Killing Millions, Treatments, VAERS, 5-Month Death Signal, Mystery Clots Embed 7.76K 31 'This Has Cost Millions Of Lives': Steve Kirsch On Suppression Of Repurposed Drugs And A Spike In Deaths 5 Months After Vaccine Rollout By Jan Jekielek American Thought Leaders / The Epoch Times November 24, 2022 Show more Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. In the studies and the anecdotes I am aware of, everyone reversed symptoms within days of getting the drug. As of January 18, 2021, the CDC estimates that 90,000 Americans will die from COVID in just the next 3 weeks. Last Checked: 03/03/2023. To scientists, giving fluvoxamine a chance means running a large trialnot giving it to individual patients in the clinic, off-label and outside the context of active data collection and analysis. I believe they made the right decision and we should be rushing to follow their advice. At that dose, no side effects were reported for his patients (I know of only one person who had mild nausea at that dose) and everyone reversed out their symptoms in an average of 3 days. Read More fluvoxamine The Fluvoxamine FAQ He has made millions from these projects, even if they have not turned him into a household name. No long haul symptoms if you start the drug ASAP after first symptoms. CETF founder Steve Kirsch accepted an invitation to discuss the findings on a weekly . Mar. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. Sadly, doctors and public health officials refuse to instruct patients to seek early treatment. Another CETF grant, though, yielded far more exciting results. Fluvoxamine - The backstory T he i nsi de st ory behi nd how f l uvoxami ne became a CO V I D t herapy By Steve Kirsch Last updated: June 3, 2021 . On his blog, Covid-19 Data Science, he has extensivelyand mercilesslyunpacked Kirschs evidence for the vaccine death claims. Enter the email address you signed up with and we'll email you a reset link. There were IRB rules that required the 65 patients to be listed in the diagrams and charts. So much for evidence-based medicine. If you start 5 days after symptoms, all bets are off. There were no studies reported out so far where fluvoxamine made things worse or neutral. It is currently approved for treatment of depression and obsessive compulsive disorder (OCD). At the beginning of the COVID-19 pandemic, Steve Kirsch created the COVID-19 Early Treatment Fund (CETF) to finance trials of off-patent drugs in an attempt to find a potent treatment that had been staring us in the face. Im taking low dosage Fluvoxamine as part of a multi-drug FLCCC protocol to alleviate some mild brain fog. I asked to give a talk about COVID at MIT, but they couldn't find a faculty member to sponsor it. Fluvoxamine is the poster child of the COVID-19 Early Treatment Fund (CETF). Over the last 18 months, the fund has granted at least $4.5 million to researchers testing the covid-fighting powers of drugs that are already FDA-approved for other diseases. NIH doesnt want you to get the drug since it would compete with Molnupiravir, so fluvoxamine will never make the NIH guidelines. Please read and agree to the disclaimer before watching this video.. Steve Kirsch On COVID Early Treatment and CensorshipSteve Kirsch is an entrepreneur and . Steve Kirsch. Months later, the site wont disclose how many doses it helped deliveror what it plans to do with user data. In three phone conversations, as well as dozens of emails, his responses to questions about claims in this story were imprecise or constantly changing. Molnupiravir followed patients for only 30 days because they know the drug is dangerous. The study was also featured on 60 Minutes. The NIH picks the drug that makes the most money for the drug companies regardless of long-term safety Molnupiravir! You will be wired for 24 hours if you dont heed my advice. If the drug is started right after symptoms, weve seen 100% prevention in hospitalization. The combined p value of the two studies is <.0001. . It was recommended back in January 2021 by a key opinion leader (KOL) panel to be used, but it took a year for the KOL meeting notes to be published because they were rejected by 10 journals. Ivermectin has a very high quality systematic review, the highest possible level in Evidence Based Medicine. If you are experiencing any odd adverse reactions, youll need to consult with your doctor ASAP. Hilary Grant-Valdez Operations Manager Tom Brunner He is the inventor of the optical mouse and one of the first Internet search engines, Infoseek. has tons of info on fluvoxamine with all the links. In November, CETF gave the group an additional $500,000 for a phase 3 clinical trial that might show conclusive proof of efficacy. Its all about NIH saying it is OK. . By March 2020, hed settled on the idea of searching for covid treatments in the pre-existing pharmacopeia. are all super cheap, effective, and available without a prescription. Now weve lost the high ground, Morris told me. While these are stunning results, less than a dozen doctors in the US are prescribing fluvoxamine today. Some people are jittery, but usually that is because the doctor either prescribed a dosage higher than 50mg twice a day or didnt notify the patient to completely avoid the list in the previous paragraph, or the patient is simply sensitive to the drug (50mg twice a day can be too much for some people). Avoid caffeine, benadryl, tylenol, and alcohol. Hes also publicly railed against what he claims is a campaign against drugs like fluvoxamine and ivermectin. The NIH never did a risk benefit analysis of this drug. CETF funded David Boulware's trials on hydroxychloroquine and the Phase 2 and Phase 3 fluvoxamine trials, among many other research projects. All have had a 100% success record in keeping their patients out of the hospital. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). , a non-profit known as the nations drug pricing watchdog, did a review of the evidence and determined that fluvoxamine evidence is superior to Molnupiravir. But Kirsch is also motivated by an unsatisfied competitive streak. You can help by bringing this document to your doctor's attention. Steve Kirsch reported that doctors commonly say (of fluvoxamine), "This is the most powerful drug in my arsenal. Steve Kirsch said scientists and clinicians are studying a host of drugs and therapeutics to create a new line of defence against the virus but clinical trials are yet to lead to conclusive. Jeffrey Morris, director of biostatistics at the University of Pennsylvania Perelman School of Medicine, has made debunking Kirschs claims something of a hobby. See more below. People are dying because of physician fear of a new treatment with a 100% success rate and a solid mechanism of action. If you start later, doctors use higher dosages and compliance becomes a bigger problem. YouTube , , , fluvoxamine, , , , , , , , , , Medium banned him for misinformation. In the second trial, it was shown to be 100% effective in long-haul COVID symptoms: None of the treated patients had any long-haul symptoms after 2 weeks compared to 60% of untreated patients having 1 or more of the 15 long-haul symptoms after two weeks, and 29% having 4 of more of the long haul symptoms after 2 weeks. The board members I spoke to say they refused to publicly promote any drugs for off-label use and tried to explain to Kirsch that its incredibly common for exciting results from small trials to disappear in larger ones. Hes also recently increased the number of Americans he claim have been killed by the vaccine from 25,0000, to 150,000, or even as many as 250,000 Americans. The claim that the spike is toxic, that came directly from the [DarkHorse episode]. Hes a genuinely good guy. Other SSRIs work as well, but fluvoxamine activates the Sigma-1 receptor the most of the SSRIs which is why it was chosen. According to its founder, serial tech entrepreneur Steve Kirsch, CETF was started in April 2020 in order to fund. If you ask your doctor for any evidence that fluvoxamine doesnt work or is harmful (like a DB-RCT which is the only thing they trust), they will show you nothing. After two weeks (since it was a tight knit community, everyone could see what was happening to the two groups), every track worker who got sick with COVID, demanded the drug. In that same IEEE Spectrum story about his then-new startup, Propel Software, he said he felt successful, but not famous. And while Morris believes that all claims about vaccine safety should be properly vettedIs it possible theres another rare side effect of the vaccines that we havent figured out yet? Yeah, its possible, he told mehe also says that he has regularly seen Kirsch manipulate evidence so that it seems to support claims that are, in reality, baseless. This is the gold standard of evidence based medicine, Article about the fluvoxamine rejection (The Verge). It is very important to educate doctors because most people rely on their doctors for advice. So instead of this paper being treated as confirming an earlier hypothesis, it was treated as generating a novel hypothesis. So why would we wait when lives are being lost? I only know of a few doctors who prescribe this off-label, all with 100% success rates. May 16, 2022. The antidepressant fluvoxamine, which is generic, but sometimes sold under the brand name Luvox, is a member of the class of drugs known as selective serotonin reuptake inhibitors (SSRIs). There are 4 outpatient studies that have been done (2 at WashU (see. Note: normally I have lots of hyperlinks to all the sources, but Im pressed for time. His appearance on an episode of anti-covid-vaccine, pro-ivermectin pundit Bret Weinsteins DarkHorse podcast, alongside Robert Malone, a prominent source of vaccine misinformation, introduced Kirsch to followers of the intellectual dark web, who have since embraced him as a fellow truth-teller. Steve Kirsch is looking for an explanation for 171,000 excess deaths. The track management was so impressed, they asked for prescriptions. 90,000 people will die in the next 3 weeks alone if we continue to ignore this drug that has caused no harm. Its all about NIH saying it is OK. Medicine today is driven by government opinion, not science. Independent appraisal committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes. . The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. Although there is evidence that fluvoxamine can prevent clinical worsening and the need for hospitalizations in outpatients with early covid-19, I have seen no good evidence that fluvoxamine is useful as a substitute for the vaccines, co-investigator Angela Reiersen wrote to me. Were having trouble saving your preferences. We pretty much practice government agency opinion medicine all over the world now, with just a few exceptions. It could do nothing. If you cant lay off the java, then try fluoxetine (Prozac). There are other non-prescription things you should always have on hand. Those who know Kirsch say this is a typical tactic. The collateral damage is that, now, a lot of people dont trust scientific leaders or the scientific community. Thats why they didnt change their recommendation when the Phase 3 trial was published in Lancet. It used to be that a Phase 3 study would do it. While Kirsch had the final say in who received grants, no one I spoke with expressed concerns about what projects had been funded, or why. But as Kirsch has clashed with the experts he initially surrounded himself with, hes grown increasingly close to others who share his perspectives on vaccineswho have, in turn, provided a large and receptive audience to his claims about a fluvoxamine conspiracy. All this was known back in January 2021 when a key opinion leader panel of experts from NIH, CDC, FDA, academia, and journal editors voted by over 2:1 to recommend that fluvoxamine be recommended to physicians to discuss with patients. Fluvoxamine for COVID-19 summary Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008 Google Docs This is a more comprehensive look at the key evidence supporting fluvoxamine: Fluvoxamine for COVID-19 In October, the group reported that, while a few patients in the placebo group ended up in the hospital, none of the patients receiving fluvoxamine got sick enough to go. Flavio Cadegiani and Steve Kirsch's studies didn't make the cut. From the French observational data (see the very last page), it appears that the biggest effect is limiting serotonin release (any SSRI will do that). None of this would really matter if Kirschs views on vaccinations were private, or shared with a limited audience. It doesnt get any better than this. Fluvoxamine has a 40 year safety track record. Reached by email, the two fluvoxamine investigators denied that there was any effort to suppress their research, and they were cautiously optimistic about their continued study. We pretty much practice government agency opinion medicine all over the world now, with just a few exceptions. All the medical journals refused to publish the meeting notes (rejected by 6 journals). Talking to Kirsch is an exhausting experience. NIH and WHO refuse to acknowledge it works since it will cause vaccine hesitancy if it is known that there is a drug that turns COVID into a mild disease. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. He pushes fluvoxamine, an anti-depression drug which despite doing very well in covid treatment studies has been strangely neglected. We should not wait for the Phase 3 RCT. . S1R can essentially turn off IRE1, so IRE1 will not activate XBP1, so that the cytokine production will decrease. Although the average effect size is 100% with a p-value of <.0001, The Fisher exact test on the combined data suggests that there is a 95% chance that the effect size is at least a 75% reduction in hospitalization rate. That work has yielded one promising candidate, the antidepressant fluvoxamine; other CETF-funded efforts have been less successful. Items included in the Television News search service. To date, the #1 drug with the most evidence to make a significant difference, without any doubt, is fluvoxamine. The NIH Guidelines committee is being very slow to react (we have no idea if they are even considering the drug because nobody is allowed to know that because all their deliberations are kept secret). thinks it should be used (and that the NIH is wrong for waiting for more clinical trials). No long haul symptoms if you start the drug ASAP after first symptoms. Over the summer, the conflict reached his most recent startup, M10. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. That way you can start immediately. Article about the rejection (Stat News) Article about the fluvoxamine rejection (The Verge) NIH is still unsure whether fluvoxamine should be used to treat COVID (article I did after the TOGETHER trial). Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital security (OneID), or e-commerce (Propel Software). Pretty much nothing changed when the Phase 3 trial confirmed fluvoxamine worked. If you take fluvoxamine, please avoid caffeine while on the drug. Why fluvoxamine isnt used. If it isn't fluvoxamine preventing hospitalization and long-haul COVID, then if you find what it is, you win. The infectious disease scientists lied to me. If you continue to get this message, To vet proposals, he recruited a powerhouse advisory board of prominent biologists, drug developers, and clinical researchers, led by world-renowned drug researcher Robert Siliciano of Johns Hopkins. Dr. Joe Ladapo wrote a brilliant op-ed in the Wall Street Journal, "Too much caution is killing COVID patients." Every earlier study of fluvoxamine (such as observational studies) showed it work and the mechanism had been shown. committee votes 11-2 that the evidence is not adequate to demonstrate a net health benefit for molnupiravir over symptomatic care alone; Paxlovid and fluvoxamine receive more favorable votes, This site requires JavaScript to run correctly. Fluvoxamine, created 37 years ago, is an inexpensive and widely available generic drug. Hes refused to accept the results of a hydroxychloroquine trial that showed the drug had no value in treating covid, for instance, instead blaming investigators for poor study design and statistical errors. The trials that were abandoned for futility werent getting events because the patients were given standard of care meds. This looks ominous, but it harmless. Please, As of November 13, fluvoxamine has been proven to work in every trial that has published results, including, studies. Note that some of these articles are inaccurate. The other doctors aren't using it either because they don't know about it or fear doing anything not approved by the CDC for treating COVID. Added to FLCCC protocols and Fareed-Tyson protocol among others. We report a real-world experience using fluvoxamine for coronavirus disease 19 (COVID-19) in a prospective cohort in the setting of a mass outbreak. Things took a final and dramatic turn once Kirsch started claiming the government was covering up vaccine deaths. After publication of the recommendation in December 2021, the NIH did absolutely nothing change their recommendation. Note that some of these articles are inaccurate. Ive used it personally at 50mg twice a day and experience no adverse events at all. For example, tylenol+caffeine+fluvoxamine can lead to serotonin syndrome. Fluvoxamine (Luvox) is a Selective Serotonin Receptor Inhibitor (SSRI) that is clinically indicated for OCD in children, and can be used off label for depression. So how did a man once intent on furthering science become a source of misinformation that undermines the very research he funded? It doesnt get much better than that. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. Get your prescription in advance of getting COVID. As Kirsch has gone deeper into the anti-vaccine scene, many professional associates have increasingly distanced themselves from him. . There is absolutely no evidence that either one of these claims is true, as Morris has carefully documented. The data we have today with just 2 clinical trials (RCT and confirmatory RWE) is compelling. At the end of May this year, Siliciano emailed the other advisors to say that Kirsch had gone off the deep end and he was cutting ties. With covid, 80% of your patient population does just peachy with no treatment at all, just a little bed rest and fluid. Steve Kirsch is a Silicon Valley philanthropist. It will be months before enrollments are complete. Stopping the meds will return you to your normal self. You cannot get any better than that. This advice is now outdated. He felt like he in good conscience had to speak out about covid, and so he made the decision to separate himself from M10, says Char, who has known Kirsch since the 1980s. Indeed, some of the most prominent people spreading misinformation about ivermectin and vaccines today began by promoting hydroxychloroquineincluding by claiming to debunk Boulwares data analysis. An MIT Technology Review investigation recently revealed how images of a minor and a tester on the toilet ended up on social media. They were all given the drug soon after symptoms and the placebo group was pure in that they were not taking any COVID drugs. Kirsch and his group received a fresh wave of attention off hopeful trials of the antidepressant fluvoxamine, which ultimately won him a spot on 60 Minutes in March. Ive used it personally at 50mg twice a day and experience no adverse events at all. 707. 4000fluvoxamine750 Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized study to prevent clinical deterioration of patients with mild coronavirus disease 2019 (COVID-19).
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